The vampires Louise, Charlotte and Nora arrive in Berlin after attacking the passengers and crew of an airplane in a flight to Paris. The leader Louise has been looking for centuries for her missed love and Charlotte misses her daughter that she saw in 1923 for the last time. Meanwhile, the smalltime pickpocket Lena steals a Russian mobster and is chased by Detective Tom. When Lena goes to a nightclub, the lesbian Louise believes that Lena is the love of her life and transforms her into a vampire. Lena initially feels lost with the transformation, but sooner she joins the trio of vampires in their nightlife. When the pack of vampires attacks a group of criminals, the police department investigates the case and hunts the women without knowing the risks that they are taking. Meanwhile the lonely Tom and the Lena fall in love with each other; but the unrequited love of Lena for Louise jeopardizes the couple.

Whilst making a documentary, filmmaker Holly meets the highly enigmatic and beautiful Vicki who claims she is a real-life vampire. By turns fascinated by and attracted to her, Holly thinks that Vicki could be her soul mate and soon the two embark on a passionate affair. However Vicki's lust for blood is growing and when Holly discovers that Vicki is pregnant with a 'vampire' baby, she is drawn into a spiral of death, deceit and betrayal from which she will never emerge.

In 1887, the powerful vampire Lilith is vanquished by a vampire council and four amulets avoid her return to the world of living. In the present days, the greedy Realtor Russel Bayne is pressing Alex Layton to sell her store of esoteric products to him. While driving back home, Russel stops his Ferrari to help a young woman that has troubles with her Volkswagen Beetle in a lonely road. However, they are attacked by a werewolf and Russel transforms into one a couple of nights later. Meanwhile, a vampire clan led by the evil Von Griem is retrieving the ancient amulets to bring Lilith back. When Von Griem's minions try to abduct Russel, Alex helps him and Russel teams up with Jacob Van Helsing and his peer group to avoid the return of the devilish Lilith.